The Monday Night Football game between the SF 49ers and the Arizona Cardinals is a true divisional battle in the NFC.

The NFL betting line for this game opened up with the 49ers (-6) and has been bet up to (-7) with over 60 percent of the backing according to the NFL Consensus. For the latest odds in the NFL For Week 8 look at Ucabet, a top-rated sportsbook! Sign up using the promo code BLITZ and get a 170% Football Bonus From Ucabet Sportsbook! That includes a  80% sportsbook freebet , 30% 3 team 7pt teaser, 20% Free football future bet and a 40% Casino Bonus! Bet on the NFL now and get this BIG BLITZ BONUS!

For the 49ers, one of the main concerns is the injury to running back Frank Gore. Gore has bruised ribs from the big game against Seattle, and he should be ready for this game but will not be 100%. This is not a good sign for a team headed on the road.

The Cardinals won at home last year breaking a 49ers five game winning streak in the series.  The home team is 4-1 against the spread in the last five games and the Cardinals are poised to pull off another upset on Monday Night Football. The Cardinals have more of an edge than just home field advantage.

The Cardinals have the edge on special teams with Patrick Peterson. Peterson leads the NFL in punt return yards – 229 through seven games and the 49ers have had many lapses on coverage this season.

Peterson loves to excel on the big stage and it does not get bigger than Monday Night Football. Another edge for the Cardinals is on defense.

“This is a huge game,” Peterson said. “One, it’s Monday night. Two, this game can pretty much solidify the leader in the division right now. … Those guys are definitely where we want to be. Those guys are the NFC West champs. We want to get where they are.”

The Cards have a defense that loves to blitz and that spells bad news for 49ers QB Alex Smith. Smith has four interceptions in two games and will be under pressure all night long. The Trends also favor the Birds

Alex+Smith+Arizona+Cardinals+v+San+Francisco+cyuN27ZWc71l 300x225 Monday Night Football Picks Against the Spread: Cardinals Clip the 49ers

Monday Night Football Picks: Arizona +7

The 49ers have a bye after this game and teams heading into the bye week are 1-13 ATS and that is just the start of the trends against the 49ers.

That is just the start of the great trends for the Cardinals. The Cardinals are 6-1-1 ATS in their last 8 vs. NFC and 4-1 ATS in their last 5 home games vs. a team with a winning road record.

This all points to one thing, a big win for the Cardinals on Monday Night Football.

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Monday Night Football Picks: Cardinals +7
 Monday Night Football Picks Against the Spread: Cardinals Clip the 49ers
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Monday Night Football Pick Against the Spread: 49ers vs Cardinals