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On Saturday the No. 1 Louisville Cardinals will get a true test when they host the No. 6 ranked Syracuse Orangemen. This marquee battle of a big college basketball Saturday will feature two of the best defenses in the country.

College Basketball Odds

Syracuse vs Louisville: Pick Against the Spread

Syracuse vs Louisville: Pick Against the Spread

The college basketball odds for the Syracuse Orange vs Louisville Cardinals game have the No. 1 team listed as (-7) point favorites. The odds have changed since its release and can be found at (-6.5) at several top-ranked sports books.

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Syracuse features a vaunted 2-3 zone that has given teams fits in the past, but the Cardinals are no slouch on the defensive side of the ball. With their man-to-man defensive pressure, the Cardinals rank in the top three nationally in several categories, including turnover margin and steals. Louisville enters this game with focus as they look to end a two-game losing streak.

Louisville center Gorgui Dieng will be the key player in this matchup as his play down low will be able to open up the zone. Syracuse will be without forward James Southerland and will have trouble breaking the Cardinals press.

Although the points look tempting in this game the Orange are 0-6-1 against the spread (ATS) in the last 7 meetings in Louisville. The Cardinals are 23-8 ATS in their last 31 games following a win and 19-7 ATS in the last 26 games overall.

After losing earlier to Duke, the Cardinals need a signature win and they will get it against the Orange.

Syracuse Orange vs Louisville Cardinals predictions

Louisville (-6.5)

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