2021 NFL Thanksgiving Picks Against the Spread: Bills vs Saints

2021 NFL Thanksgiving Picks Against the Spread: Bills vs Saints

The Buffalo Bills were once considered Super Bowl contenders but after some ugly losses, they look as though they may not win the AFC East. Injuries and some bad losses have hurt the Bills, but they have a chance to make up ground on Thanksgiving night against the New Orleans Saints. The toughest 2021 NFL Thanksgiving picks against the spread for Thanksgiving to make might just be on this game.

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Bills vs Saints

The Saints have failed to live up to expectations this season, but it is clear that injuries are to blame. Running back Alvin Kamara missed the last game and he is expected to miss this game as well. That can make things difficult for the rest of the Saints running backs. Buffalo has given up the 11th fewest yards per attempt. The Saints are 3-7 ATS against a team with a winning record, but they need to get this win if they hope to stay in the playoff race.

If the Bills want to win they will have to figure out a way to take down a Saints rushing defense that leads the league.  They will need Devin Singletary to put together a solid rushing game with Zach Moss to open up the passing lanes.

2021 NFL Thanksgiving Picks Against the Spread

The Saints extended the contract of QB Tayson Hill and it comes at an interesting time. The team likes Hill and he can run and throw. He has completed 71 percent of his passes and brings a new look to an offense that is in desperate need of a boost.  The Bills are a bad bet as a favorite. They are 1-3-1 ATS as chalk and 0-5 ATS in the last five meetings with New Orleans. The Saints are a very impressive 35-17 ATS as an underdog and Hill will lead this team to victory on Thanksgiving night.

Saints +5.5


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