NFL Week 10 picks against the spread

NFL Week 10 picks against the spread for every game

Week 10 is a pivotal week in the National Football League. The contenders are starting to rise to the top and the pretenders are fighting for their chance to make the playoffs. The best sportsbooks have put up the betting lines for this week. Now is the time to do your homework and bet on the NFL Week 10 picks against the spread.

The best handicappers gather all of the information before wagering and we are here to help. Our interactive board below has all of the odds, sports betting bonuses, and free picks for this week in the NFL.

The games will be updated every day leading up to kickoff. Click on any matchup below to be taken to the betting preview for the week. Mini quick-hitting previews and picks are also posted below the odds board. This is the time to get all of the information, bet on the big games, and win money!

Check back for daily updates!

Matchup Time Spread Over/Under
Colts at Titans 8:20 p.m. ET Thursday Titans -2.5 [BET HERE] 49
Bengals at Steelers 4:25 p.m. ET Sunday Steelers -8 [BET HERE] 47.5
Washington at Lions 1 p.m. ET Sunday Lions -3.5 [BET HERE] 46.5
Texans at Browns 1 p.m. ET Sunday Browns -3 [BET HERE] 54
Jaguars at Packers 1 p.m. ET Sunday Packers -14 [BET HERE] 53
Eagles at Giants 1 p.m. ET Sunday Giants +3.5 [BET HERE] 44
Buccaneers at Panthers 1 p.m. ET Sunday Panthers +6 [BET HERE] 49.5
Broncos at Raiders 4:05 p.m. ET Sunday Raiders -4.5 [BET HERE] 51
Bills at Cardinals 4:05 p.m. ET Sunday Cardinals -1.5 [BET HERE] 55.5
Seahawks at Rams 4:25 p.m. ET Sunday Rams -1.5 [BET HERE] 55.5
49ers at Saints 4:25 p.m. ET Sunday Saints -9 [BET HERE] 51
Ravens at Patriots 8:20 p.m. ET Sunday Patriots +7 [BET HERE] 41.5
Vikings at Bears 8:15 p.m. ET Monday Vikings -2.5 [BET HERE] 44.5
Chargers at Dolphins 4:05 p.m. ET Sunday Dolphins -2.5 [BET HERE] 47.5

Odds courtesy of the best sportsbook to bet on the NFL. 

Teams on bye: Kansas City Chiefs, Atlanta Falcons, Dallas Cowboys, New York Jets

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Jaguars vs Packers

It is hard to bet against Aaron Rodgers and the Packers right now. Rodgers is on pace for an MVP season and it’s unlikely that Jacksonville will slow him down. This week he faces a Jags defense that allowed 30 or more points in six straight losses, before the last game against the Texans. This explains why the Packers are a two-touchdown favorite heading into this game. But before you run to the sportsbook and load up on the Packers, think again.

The weather in Green Bay calls for heavy winds at times, which always makes for a difficult passing day. The Packers are just 1-5 ATS in the past six games where they were favored by double digits and in a game that may be low scoring due to weather, this spread will be hard to cover.

Rookie Jake Luton looked impressive in the loss to the Texans and he will have all the reps in practice leading up to game time. The Jaguars are 19-9-3 ATS in their last 31 games after allowing more than 250 yards passing in their previous game. Do not be surprised if the Jaguars come very close to pulling off the biggest upset of the year.

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Eagles vs Giants

The NFC East may be a weak division, but it makes things interesting down the stretch. Although the teams do not have many wins, they are all still alive for a shot at the playoffs. The Giants host the Eagles in a must-win game for the playoff race, but if you are betting on Big Blue you have to be cautious. The Gmen are 3-11 both straight-up and ATS in their past 14 games played at the MetLife Stadium.

The Eagles have now won eight straight, 12 of 13, and 21 of 25 against New York, but there is every reason to believe that this game will be different. The Giants are the better team. They should have won the first meeting and they have better units in almost every aspect.

The Eagles are getting healthy. Running back Miles Sanders is at 100 percent and the Eagles get back help at wide receiver.

This explains why over 59 percent of the money is on the Eagles. So what is the difference? The Giants are a better defensive unit and they are well-coached. The Eagles are hard to bet as favorites since they are 1-5 ATS in their last 6 games as a favorite. The Giants are 11-0 ATS  since Oct 2018, as a dog facing a team allowing at least 22.5 points per game, and the trends don’t stop there. The Giants are 12-3-1 ATS against a team with a losing record and they win this Sunday against the Eagles.

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Buccaneers vs Panthers

The Tampa Bay Buccaneers look to rebound against the Panthers after an embarrassing loss to the Saints. Unfortunately, they have to face the ultimate underdog in QB Teddy Bridgewater, look at his numbers as an underdog, they are SICK! 

Tampa Bay bettors usually love to bet on the Bucs, but they are backing off. The public is only betting on Tampa Bay at a 58 percent rate. IT may seem smart to bet against a Buccaneers team with flaws, but the Panthers will once again be without their best player.


The Buccaneers had to deal with travel issues leading up to this game, which would be considered a distraction for football teams without leadership.


There is not one QB that works harder after a loss than Tom Brady. The Panthers are 1-6-1 ATS in their last 8 home games and 1-4-1 ATS in their last 6 games as a home underdog. The Panthers have fought and they play tough, but they are simply outmatched in this game. The Buccaneers are 9-2-1 ATS in their last 12 games following a double-digit loss at home. Good players and coaches respond after a loss and that is exactly what will happen this week.

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Washington vs Lions

It took a minute but the Washington Football team announced Alex Smith as the starter at QB. This may have been a bit surprising considering that Smith did not perform well when inserted into the lineup a week ago. If history tells you anything, this is not a good move for Washington. Since 2016, Washington is 1-31-1 when allowing more than 24 points in a game, and that is not only a bad sign, but it is the worst mark in the National Football League. However, this is not the same Washington team that you have seen in the past.

They are well-coached, they have better skill players and the fight in every game they play in. This is the important thing that you need to know if you are betting on this game. The Lions are 0-7 straight-up in the last seven home games. Yet, the sportsbooks are posting this team as a favorite?

The Lions are 9-25 ATS in their last 34 games after allowing more than 30 points in their previous game and they are underperforming for the coaching staff. Betting a favorite that is 5-14 ATS in their last 19 games overall, is a mistake.

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Texans vs Browns

When you research information to bet on the National Football League you have to check everything. Injuries are often the first place that a handicapper will start. For example, in this game, Nick Chubb is activated and ready to go for the Browns and David Johnson is inactive and will be out for the Texans. However, there is one area that often goes overlooked and that is the weather. This game will be influenced by the weather.

The over/under in this game has dropped nine points and sits at 46.5 after opening at 55 at most sportsbooks. This may turn into a ground-and-pound type of game that favors the Browns and the rushing attack. This is what the Browns expect to do against a Houston defense that is dead-last in the NFL against the run this season, allowing an embarrassing 159.5 rushing yards per game. The Texans are 1-7 ATS on the season, which is tied with the Jets for the second-worst mark in the NFL this year. The Browns are not overly impressive against the spread, but they are 4-0 ATS in their last 4 home games against a team with a losing road record.

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Broncos vs Raiders

There is nothing like a good old fashioned AFC West grudge match. Regardless of the records, it is always an entertaining game when the Raiders and the Broncos meet on the field. All of a sudden, the Broncos are a pass-happy squad. In the last three games, Drew Lock is averaging 43 pass attempts per game while averaging 272 passing yards. The Raiders have been the best bet in this series, going 5-0 ATS in the last five meetings, but that may change this year. The Broncos are 7-3 ATS in their past 10 road games and the Raiders are 2-7-1 ATS In their past 10 games where they were favored by three points or more. The Broncos have excelled at garbage points and covering in the last few minutes of the game and they will do it again Sunday against the Silver and Black.

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Bills vs Cardinals

The Bills dominated the Seahawks a week ago and the fanbase is now sure that they have a contender. That theory will be tested when Buffalo travels to Arizona to battle the Cardinals. Unfortunately for Buffalo,l they will not be at full strength for this matchup.

The Bills still have the majority of the key personnel in this game, but it is something to make note of before betting on the game. Buffalo will want to get off to a quick start since the Bills are 10-0 if they have the lead after the first quarter and 14-0 if they hold the lead at the half. The Cardinals will be looking for a better defensive effort after they let Tua run wild last week. The birds are 11-5 ATS in their last 16 games after allowing more than 30 points in their previous game, so expect a better performance defensively.

Despite losing last week, QB Kyler Murray is still putting up gaudy numbers. The Cardinals have posted 30 or more points in three straight games. The Bills are 1-4-1 ATS in their last 6 road games and 1-3-1 ATS in their last 5 games as an underdog. With a bye week up next for Buffalo, this is a classic let-down spot and the best bet is the Cardinals.

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Seahawks vs Rams

The Seattle Seahawks are one of the best teams in the league, but after getting embarrassed last week in Buffalo, they have some questions to answer. Handicappers are running to bet on Seattle. After all, Russell Wilson is 24-12-4 ATS off a loss and 23-9-2 ATS as an underdog. This year in the NFL road dogs off of a loss are 26-15 ATS, but before you place a bet on Seattle, think twice. The defense is bad. How bad you ask? They rank last in the NFL allowing 456 yards per game and in the game against Buffalo they allowed 459 more yards and 44 more points in the ugly loss. It was the most points they’d allowed since Pete Carroll took over as coach. They will get some help this week, but they have to get better as a unit.

The Rams are 4-1 straight-up in the last five meetings and they are averaging 33.6 per game. The Rams have extra rest and they are 4-1-1 ATS in their last 6 games following a bye week. The Seahawks are 1-4 ATS in their last 5 when they face a team from the NFC West and they are 2-6 ATS in their last 8 meetings in Los Angeles. Seattle has some issues and LA wins big on Sunday.

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49ers vs Saints

The Saints crushed the Buccaneers in the last outing and they are now being crowned Super Bowl champs by the media. The 49ers limped into a Thursday night showdown and were trounced by Aaron Rodgers and the Green Bay Packers. What a difference a week makes. Based on the last results, the Saints are attracting the betting cash and the spread in this game has moved four points. The sportsbooks have the Saints as 10 point favorites for that game. This is a clear overreaction.

This is not a good spot for the Saints since they are 1-4 ATS in their last 5 games as a home favorite, 1-4 ATS in their last 5 home games, and 1-5 ATS in their last 6 games following a straight-up win. San Francisco coach Kyle Shanahan is deadly with extra time to prepare. That time will also give the coach more bodies to put on the field in this game. The 49ers are 6-2 ATS in their last 8 games as a road underdog and although they may not win, 10 points are just too much.

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Bengals vs Steelers

After impressive wins, many expect the Steelers to have a letdown game against the Bengals. Although the Bengals are not ready to be contenders, they have played well this season. Steelers QB Ben Roethlisberger has to be quarantined early in the week, but he has been cleared for the game. The unsettling news and the promising play led the public to bet on Joe Burrow and the underdog Bengals in this game. That’s a big mistake.

If the Bengals have a weakness it is along the offensive line. Setting up the run game top open the passing game will not be easy for Cincinnati since RB Joe Mixon has been ruled out. If there is one thing that the Steelers can take advantage of, it is a weak pass protecting unit.

The Steelers game against the Cowboys is the main reason that the public is backing the Bengals. The Steelers are 7-2 ATS in their last 9 home games against a team with a losing road record and they are 6-2 ATS in their last 8 home games. It’s not fair to look at the history between these two teams since it is the first year for Burrow, but the Steelers have gone 12-1 straight-up and 10-3 ATS in the last 13 meetings.

The poor game against Dallas will motivate Pittsburgh in this game. It may be close early, but it won’t be in the end.

Place your bets on the Steelers -7 and get a bonus boost for NFL Sunday as well as a $35 Free Chip for Black Friday!


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