NFL Week 1 2021 Picks Against the Spread

NFL Week 1 2021 Picks Against the Spread

The NFL season kicked off on Thursday with an incredible game between the Tampa Bay Buccaneers and the Dallas Cowboys. It will get even better today when the full schedule begins. Betting on the NFL is not easy. In order to help out, we have compiled our picks to watch for week one!

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NFL Week 1 2021 Picks Against the Spread

Bet on the Carolina Panthers -3.5 over the New York Jets

Sam Darnold gets a chance at early revenge against his former team and this game sets up nicely. Panthers running back Christian McCaffrey is healthy and the Jets do not have anyone that will be able to cover him in pass plays. Matt Rhule has this team believing and the defense has improved under his guidance. Now with all of his players in place, the Panthers will have a double-digit win.

The Jets are 19-39-4 ATS in the last 62 road games and rookie Zach Wilson, will not win his first game on the road.

Pick: Panthers -3.5

Bet on the Pittsburgh Steelers +6.5 over the Buffalo Bills

Josh Allen and the Buffalo Bills are AFC title contenders, but this is a highly inflated line for the opener. Both teams boast improved and demanding defenses that will be on display. Ben Roethlisberger has something to prove as he faces scrutiny and taunts of being washed. This Steelers offense will get a boost in the running game with the debut of rookie Najee Harris and that balance will keep this game close. The Steelers thrive as an underdog with a 23-8-2 ATS record. When they are dogs of six or more they are 8-3 ATS under Mike Tomlin.

Pick: Steelers +6.5

Bet on the Cleveland Browns +5.5 over the Kansas City Chiefs

This is going to be a fun game to watch. The Chiefs have one of the best offensive lines in football and will face an incredibly talented defense in Cleveland. But the Browns offense will have the ability to run the ball against the Chiefs and keep the ball away from Patrick Mahomes and Co. The Chief’s record in week 1 under Andy Reid is remarkable, but this game will come down to the end.

The Chiefs are just 2-9 ATS in the last 11 games overall and 1-5 ATS in the last six home games.

Pick: Browns +5.5

Bet on the Seattle Seahawks -3 over the Indianapolis Colts

The Colts will get a first look at Carson Wentz as they draw a tough Seattle team in the opener. Wentz is 0-4 in his starts against Seattle with six interceptions. The Colts are known for losing the opener.


To make matters worse, the Colts are 1-11-1 ATS in week 1. The Colts will have to stop a revamped Seahawks offense that will focus on Russell Wilson and allow him to open things up. The Seahawks are 12-1 with Wilson at QB in the Eastern time zone and they have no problem starting the season on the road.

Pick: Seahawks -3

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